FLUKOZONE
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FLUCASONE AQUEOUS NASAL SPARY
Fluticasone Propionate Aqueous Nasal Spray 50 mcg/metered dose
Fluticasone propionate is a white to off-white powder. It is freely soluble in dimethyl sulfoxide and dimethylformamide, sparingly soluble in acetone, dichloromethane, ethyl acetate and chloroform, slightly soluble in methanol and 95% ethanol, and practically insoluble in water. Fluticasone propionate decomposes without melting. Onset of decomposition occurs at about 225°C.
Chemical Name: S-fluoromethyl 6α,9α -difluoro-11β -hydroxy-16α -methyl-3-oxo-17α –Propionyloxyandrosta -1,4-diene-17β.-Carbotioate.
PHARMACOLOGY
Fluticasone propionate was shown to be approximately twice as potent in topical activity as beclomethasone dipropionate according to the McKenzie vasoconstrictor assay. In human volunteers, fluticasone propionate was 9.5 times more potent than fluocinolone acetonide and intermediate in potency between betamethasone-17-valerate (less potent) and clobetasol-17-propionate (more potent).
Although relative vasoconstrictor activity does not necessarily imply similar relative therapeutic efficacy, evidence for local anti-inflammatory action without systemic effects has been demonstrated by studies in laboratory animals and confirmed in human clinical pharmacology studies.