LDROPZINE
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LDROPZINE SF COUGH SYRUP
Levodropropzine cough syrup 30mg 5ml
Levodropropizine, the (-)-(S)-isomer of dropropizine, is a cough suppressant with peripheral action. It decreases the excitability of tracheobronchial receptors thus suppressing the cough reflex.
MECHANISM OF ACTION
Levodropropizine is a non-opioid agent whose peripheral antitussive action may result from its modulation of sensory neuropeptide levels within the respiratory tract. In particular, levodropropizine exerts its antitussive effect through an inhibitory action at the level of the airway sensory nerves and it has been shown to be able to inhibit in vitro the release of neuropeptides from C-fibers. In addition, in anaesthetized cats, it markedly reduces the activation of C-fibres and abolishes the associated reflexes. The activity of levodropropizine on airway sensory units other than the C-fibres has not been investigated.